Exenatide and rare adverse events.
نویسندگان
چکیده
n engl j med 358;18 www.nejm.org may 1, 2008 1969 Editor’s note: We received 1610 responses, from 85 countries, for this medical mystery. Sixty-two percent of respondents were physicians in practice, 21% were physicians in training, and 12% were medical students. Of the respondents, 65% identified some type of diaphragmatic hernia on the radiograph, which revealed a retrocardiac gastric shadow (Panel A). Specifically, 46% suggested a hiatal hernia, and 13% proposed another type of diaphragmatic defect such as Bochdalek’s or Morgagni’s hernia; 6% correctly identified gastric volvulus. The remaining 35% of respondents suggested a variety of diagnoses, including aortic aneurysm, Boerhaave’s syndrome, Zenker’s diverticulum, thymoma, pulmonary abscess, and achalasia.
منابع مشابه
Safety and tolerability of exenatide once weekly in patients with type 2 diabetes: an integrated analysis of 4,328 patients
BACKGROUND Exenatide once weekly (QW) is a glucagon-like peptide-1 receptor agonist (GLP-1RA) for the treatment of type 2 diabetes. Safety and tolerability are key considerations in treatment selection. This analysis examines the safety and tolerability profile of exenatide QW, other approved GLP-1RAs (exenatide twice daily and liraglutide once daily), and a pooled population of commonly used n...
متن کاملSafety and tolerability of exenatide twice daily in patients with type 2 diabetes: integrated analysis of 5594 patients from 19 placebo-controlled and comparator-controlled clinical trials
BACKGROUND Exenatide twice daily is a first-in-class glucagon-like peptide receptor agonist approved for the treatment of type 2 diabetes. The objective of this analysis was to evaluate the safety profile of exenatide twice daily and to compare its profile with that of a pooled comparator (placebo and insulin) in patients with type 2 diabetes. METHODS Data from 19 completed, randomized, contr...
متن کاملUpper and/or lower gastrointestinal adverse events with glucagon‐like peptide‐1 receptor agonists: Incidence and consequences
AIMS To characterize gastrointestinal adverse events (AEs) with different glucagon-like peptide-1 receptor agonists (GLP-1RAs). METHODS Two retrospective intention-to-treat analyses of 6-month patient-level data were conducted. Data from three studies comparing exenatide once weekly (n = 617) with exenatide twice daily (n = 606) were pooled, and one (DURATION-6) comparing exenatide once weekl...
متن کاملEffectiveness and safety of exenatide in Korean patients with type 2 diabetes inadequately controlled with oral hypoglycemic agents: an observational study in a real clinical practice
BACKGROUND Randomized clinical trials have shown the efficacy and safety of short-acting exenatide in patients with type 2 diabetes mellitus (T2DM). The aim of this observational study was to investigate the effectiveness and safety of exenatide twice a day in Korean patients with T2DM who are suboptimally controlled with oral hypoglycemic agents. METHODS This study was a post hoc analysis of...
متن کاملComparative efficacy of exenatide versus insulin glargine on glycemic control in type 2 diabetes mellitus patients inadequately treated with metformin monotherapy.
PURPOSE Comparative efficacy of exenatide versus insulin glargine primarily on glucemic control, and secondarily on body mass index (BMI), lipid profile and blood pressure, in type 2 diabetes mellitus (T2DM) patients suboptimally treated with metformin monotherapy. MATERIAL/METHODS Forty-seven inadequately treated T2DM patients on metformin assigned to exenatide (n=18) or insulin glargine (n=...
متن کاملExenatide (Byetta) as a novel treatment option for type 2 diabetes mellitus.
Exenatide is the first drug in the incretin mimetic class and is indicated for treatment of type 2 diabetes mellitus. Although structurally similar to the native glucagon-like peptide, this synthetic form has a much longer duration of action. Randomized trials have shown exenatide to be efficacious in improving glycemic control when combined with either metformin or a sulfonylurea. The dose is ...
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ورودعنوان ژورنال:
- The New England journal of medicine
دوره 358 18 شماره
صفحات -
تاریخ انتشار 2008